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Fish Oil Ameliorates High-Fat Diet Induced Male Mouse Reproductive Dysfunction via Modifying the Rhythmic Expression of Testosterone Synthesis Related Genes
- Source :
- International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1325, International Journal of Molecular Sciences, Vol 19, Iss 5, p 1325 (2018), International Journal of Molecular Sciences
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- The present study aims to investigate the protective effects of ω-3 polyunsaturated fatty acids (ω-3PUFAs) against high-fat diet induced male mouse reproductive dysfunction and to explore circadian regulation mechanisms. Male C57BL/6 mice were randomly divided into three groups and fed a normal chow diet (control group, CON), a high-fat diet (HFD group) or a HFD supplemented with fish oil (FO group) for 12 weeks. After 12 weeks of feeding, the body weight and the ratio of perinephric and epididymal fat weight to body weight were significantly higher in the HFD group compared with the CON group. The supplement of fish oil rich in ω-3PUFAs only slightly reduced the HFD-induced obesity but remarkably ameliorated HFD-induced dyslipidemia, sexual hormones disorder, testicle lesions and germ cell apoptosis. Fish oil supplementation restored the expression of steroid synthesis associated genes in HFD fed mouse and flattened the HFD-induced oscillations in circadian genes' expression. Fish oil supplementation prevented HFD-induced male mouse reproductive dysfunction and modified the rhythmic expression of testosterone synthesis related genes.
- Subjects :
- Male
0301 basic medicine
Apoptosis
Testicle
fish oil
lcsh:Chemistry
Mice
Testis
Testosterone
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
digestive, oral, and skin physiology
food and beverages
General Medicine
Fish oil
Circadian Rhythm
Computer Science Applications
high-fat diet
medicine.anatomical_structure
Polyunsaturated fatty acid
medicine.medical_specialty
Biology
Diet, High-Fat
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
Fatty Acids, Omega-3
medicine
Animals
Circadian rhythm
Physical and Theoretical Chemistry
Molecular Biology
Infertility, Male
Dyslipidemias
Organic Chemistry
nutritional and metabolic diseases
medicine.disease
Obesity
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
circadian rhythms
reproduction function
Dyslipidemia
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1325
- Accession number :
- edsair.doi.dedup.....8f8410ef0d4846789e92a610757def6b
- Full Text :
- https://doi.org/10.3390/ijms19051325