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Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy
- Source :
- Internal and Emergency Medicine
- Publication Year :
- 2020
- Publisher :
- Springer International Publishing, 2020.
-
Abstract
- The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention in the literature. The aim of the present study was to evaluate the role of cardiac involvement and of respiratory failure in a cohort of COVID-19 patients hospitalized in an academic hospital in Lombardy, one of the most affected Italian (and worldwide) regions by the epidemic. The study included 405 consecutive patients with confirmed COVID-19 admitted to a medical ward from February 25th to March 31st, 2020. Follow-up of surviving patients ended either at hospital discharge or by July 30th, 2020. Myocardial injury was defined on the basis of the presence of blood levels of hs-TnI above the 99th percentile upper reference limit. Respiratory function was assessed as PaO2/FiO2 (P/F) ratio. The primary end-point was death for any cause. During hospitalization, 124 patients died. Death rate increased from 7.9% in patients with normal hs-TnI plasma levels and no cardiac comorbidity to 61.5% in patients with elevated hs-TnI and cardiac involvement (p
- Subjects :
- Male
medicine.medical_specialty
Pneumonia, Viral
Population
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Tertiary referral hospital
Polymerase Chain Reaction
Tertiary Care Centers
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Internal medicine
Outcome Assessment, Health Care
Internal Medicine
Humans
Medicine
Respiratory function
030212 general & internal medicine
education
Pandemics
Aged
education.field_of_study
business.industry
Mortality rate
Troponin I
COVID-19
Middle Aged
medicine.disease
Prognosis
Comorbidity
Im - Original
Cardiac injury
Hospitalization
Respiratory failure
Italy
Cardiovascular Diseases
Cohort
Emergency Medicine
Breathing
Female
Coronavirus Infections
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 19709366 and 18280447
- Database :
- OpenAIRE
- Journal :
- Internal and Emergency Medicine
- Accession number :
- edsair.doi.dedup.....8f8540c5df918819ceca90ed31a84094