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Inflammatory response and IgE sensitization at early age
- Source :
- Pediatric Allergy and Immunology, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. 〈10.1111/pai.12072〉, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. ⟨10.1111/pai.12072⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; BACKGROUND: Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis. We examined the associations between low-grade inflammation and the development of allergic sensitization, atopic dermatitis (AD), and asthma at the age of 4.5 yr. METHODS: We studied 636 children participating in the PASTURE study in Finland, Germany, Austria, France, and Switzerland. Data of environmental factors, doctor-diagnosed AD, and asthma were collected by questionnaire. The serum high-sensitivity C-reactive protein (CRP) values were measured at the age of 1 yr, and serum-specific IgE concentrations (sIgE) at the age of one and 4.5 yr. Analyses were made by logistic regression analysis. RESULTS: The risk of allergic sensitization at the age of 4.5 yr was decreased in children who had increased CRP levels at the age of 1 yr (level in the highest vs. lowest quartile: aOR 0.48, 95% CI 0.24-0.95; p = 0.014). The risk of AD and asthma was not significantly related to CRP. CONCLUSION: The findings confirm that elevated levels of CRP at early age showed association with decreased allergic sensitization later in life. Our results suggest that poor inflammatory response could predispose for IgE sensitization.
- Subjects :
- MESH: Inflammation
Hypersensitivity, Immediate
Rural Population
Allergy
Urban Population
MESH : Risk
MESH : Child, Preschool
Immunoglobulin E
MESH : Hypersensitivity, Immediate
Allergic sensitization
0302 clinical medicine
MESH: Rural Population
Surveys and Questionnaires
Immunology and Allergy
2. Zero hunger
0303 health sciences
MESH: Risk
MESH : Prognosis
biology
MESH: Immunoglobulin E
MESH : Questionnaires
MESH : Infant
Atopic dermatitis
MESH: Follow-Up Studies
Prognosis
MESH: Infant
3. Good health
Europe
MESH: Urban Population
C-Reactive Protein
Child, Preschool
MESH : Urban Population
Hay fever
MESH: Hypersensitivity, Immediate
Risk
Immunology
MESH: Environmental Exposure
MESH : Europe
MESH : Immunoglobulin E
MESH: Prognosis
[ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health
03 medical and health sciences
Hygiene hypothesis
MESH: C-Reactive Protein
medicine
Humans
030304 developmental biology
Asthma
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health
Inflammation
MESH: Humans
MESH : Inflammation
business.industry
MESH: Questionnaires
C-reactive protein
MESH: Child, Preschool
MESH : Humans
Infant
MESH : Follow-Up Studies
Environmental Exposure
MESH : C-Reactive Protein
medicine.disease
MESH : Rural Population
030228 respiratory system
Pediatrics, Perinatology and Child Health
biology.protein
MESH: Europe
business
MESH : Environmental Exposure
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 09056157 and 13993038
- Database :
- OpenAIRE
- Journal :
- Pediatric Allergy and Immunology, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. 〈10.1111/pai.12072〉, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. ⟨10.1111/pai.12072⟩
- Accession number :
- edsair.doi.dedup.....8f8e5a05f6c27dcbc61547dbbf78427e
- Full Text :
- https://doi.org/10.1111/pai.12072〉