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Inflammatory response and IgE sensitization at early age

Authors :
Josef Riedler
Outi Vaarala
Roger Lauener
Erika von Mutius
Juha Pekkanen
K. Mustonen
Leea Keski-Nisula
Juliane Weber
Petra Ina Pfefferle
Anne Hyvärinen
Caroline Roduit
Bianca Schaub
Jon Genuneit
Charlotte Braun-Fahrländer
Jean-Charles Dalphin
L. Orivuori
Laboratoire Chrono-environnement ( LCE )
Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC )
Institute of Epidemiology
Universität Ulm
Asthma and Allergy Department
University Children's Hospital-Ludwig Maximilians University
Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE)
Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC)
Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
Universität Ulm - Ulm University [Ulm, Allemagne]
Source :
Pediatric Allergy and Immunology, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. 〈10.1111/pai.12072〉, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. ⟨10.1111/pai.12072⟩
Publication Year :
2013
Publisher :
HAL CCSD, 2013.

Abstract

International audience; BACKGROUND: Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis. We examined the associations between low-grade inflammation and the development of allergic sensitization, atopic dermatitis (AD), and asthma at the age of 4.5 yr. METHODS: We studied 636 children participating in the PASTURE study in Finland, Germany, Austria, France, and Switzerland. Data of environmental factors, doctor-diagnosed AD, and asthma were collected by questionnaire. The serum high-sensitivity C-reactive protein (CRP) values were measured at the age of 1 yr, and serum-specific IgE concentrations (sIgE) at the age of one and 4.5 yr. Analyses were made by logistic regression analysis. RESULTS: The risk of allergic sensitization at the age of 4.5 yr was decreased in children who had increased CRP levels at the age of 1 yr (level in the highest vs. lowest quartile: aOR 0.48, 95% CI 0.24-0.95; p = 0.014). The risk of AD and asthma was not significantly related to CRP. CONCLUSION: The findings confirm that elevated levels of CRP at early age showed association with decreased allergic sensitization later in life. Our results suggest that poor inflammatory response could predispose for IgE sensitization.

Details

Language :
English
ISSN :
09056157 and 13993038
Database :
OpenAIRE
Journal :
Pediatric Allergy and Immunology, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. 〈10.1111/pai.12072〉, Pediatric Allergy and Immunology, Wiley, 2013, 24 (4), pp.395-401. ⟨10.1111/pai.12072⟩
Accession number :
edsair.doi.dedup.....8f8e5a05f6c27dcbc61547dbbf78427e
Full Text :
https://doi.org/10.1111/pai.12072〉