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Efficacy and Safety of Artesunate-Amodiaquine versus Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum Malaria in Sentinel Sites across Côte d’Ivoire
Efficacy and Safety of Artesunate-Amodiaquine versus Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum Malaria in Sentinel Sites across Côte d’Ivoire
- Source :
- Malaria Research and Treatment, Malaria Research and Treatment, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Publishing Corporation, 2015.
-
Abstract
- Two years after the introduction of free Artesunate-Amodiaquine (ASAQ) and Artemether-Lumefantrine (AL) for the treatment of uncomplicated malaria in public health facilities in Côte d’Ivoire, we carried out this study to compare their efficacy and tolerability in three surveillance sites. It was a multicentre open randomised clinical trial of 3-day ASAQ treatment against AL for the treatment of 2 parallel groups of patients aged 2 years and above. The endpoints were (1) Adequate Clinical and Parasitological Response (ACPR) at day 28 and (2) the clinical and biological tolerability. Of the 300 patients who were enrolled 289, with 143 (49.5%) and 146 (50.5%) in the ASAQ and AL groups, respectively, correctly followed the WHO 2003 protocol we used. The PCR-corrected ACPR was 99.3% for each group. More than 94% of patients no longer showed signs of fever, 48 hours after treatment. Approximately 78% of the people in the ASAQ group had a parasite clearance time of 48 hours or less compared to 81% in the AL group (p=0.496). Both drugs were found to be well tolerated by the patients. This study demonstrates the effectiveness and tolerability of ASAQ and AL supporting their continuous use for the treatment of uncomplicated P. falciparum malaria infection in Côte d’Ivoire.
- Subjects :
- Pediatrics
medicine.medical_specialty
Artemether/lumefantrine
biology
Article Subject
Epidemiology
business.industry
Artesunate/amodiaquine
Plasmodium falciparum
Cote d ivoire
biology.organism_classification
medicine.disease
Uncomplicated malaria
lcsh:Infectious and parasitic diseases
Clinical trial
Infectious Diseases
Tolerability
medicine
Clinical Study
lcsh:RC109-216
business
Malaria
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20908075
- Database :
- OpenAIRE
- Journal :
- Malaria Research and Treatment
- Accession number :
- edsair.doi.dedup.....8fb2ffd353b665395fa82ddd9f080d7c
- Full Text :
- https://doi.org/10.1155/2015/878132