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Genetic Variants of Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity and Ageing Study
- Source :
- The journal of nutrition, health & aging. 24:198-204
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Recently, elevated homocysteine was reported to be associated with frailty in cross-sectional studies. However, whether homocysteine is causally associated with frailty is unknown. Here, we explore the inter-relationships between five non-synonymous genetic variants of homocysteine metabolic four genes, plasma homocysteine levels, and frailty. Data of 1480 individuals aged 70–87 years from the ageing arm of Rugao Longevity and Ageing Study were used. Five variants of the four homocysteine metabolic enzyme genes were genotyped. Frailty was defined using Fried’s phenotype criteria. The percentage of high homocysteine (>15μmol/L) is 33.3%. Two functional variants that decrease methylenetetrahydrofolate reductase (MTHFR) activities, C677T (Ala222Val, rs1801133) and A1298C (Glu429Ala, rs1801131), were significantly associated with increased homocysteine levels (β=−1.16, p=0.01; and β=1.46, p
- Subjects :
- Male
Aging
medicine.medical_specialty
Homocysteine
030309 nutrition & dietetics
media_common.quotation_subject
Longevity
Population
Medicine (miscellaneous)
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Genotype
medicine
Humans
030212 general & internal medicine
education
Aged
media_common
Aged, 80 and over
0303 health sciences
education.field_of_study
Polymorphism, Genetic
Nutrition and Dietetics
Frailty
biology
business.industry
Confounding
Cross-Sectional Studies
Endocrinology
chemistry
Ageing
Methylenetetrahydrofolate reductase
biology.protein
Biomarker (medicine)
Female
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 17604788 and 12797707
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- The journal of nutrition, health & aging
- Accession number :
- edsair.doi.dedup.....8fc3208d73e04f6b11369dc78412cefe