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Small nucleolar host gene 6 promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis
- Publication Year :
- 2018
- Publisher :
- D.A. Spandidos, 2018.
-
Abstract
- Esophageal cancer (ESCC) is one of the most common causes of cancer-associated mortality in China. The present investigation reveals that non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), exert a significant effect on the initiation, development and metastasis of malignant tumors, including ESCC. However, to the best of our knowledge, the function of non-protein-coding genes that host small nucleolar RNAs has not been investigated in cancer, particularly in ESCC. The expression of small nucleolar host gene 6 (SNHG6) in 70 ESCC tissues and paired adjacent tissues was measured by reverse transcription quantitative polymerase chain reaction. Analysis demonstrated that SNHG6 expression was significantly increased in ESCC tissues, and associated with tumor size (P=0.040) and Tumor-Node-Metastasis stage (P
- Subjects :
- 0301 basic medicine
Cancer Research
Gene knockdown
Oncogene
Cell growth
Cell
Cancer
Articles
Cell cycle
Biology
medicine.disease
Molecular medicine
digestive system diseases
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Real-time polymerase chain reaction
Oncology
030220 oncology & carcinogenesis
medicine
Cancer research
neoplasms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8fe2c3cf0e89c332f5489ffb0a1aa071