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A comprehensive and perspective view of oncoprotein SET in cancer
- Source :
- Cancer Medicine, Cancer Medicine, Vol 7, Iss 7, Pp 3084-3094 (2018)
- Publication Year :
- 2018
-
Abstract
- SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.
- Subjects :
- 0301 basic medicine
Cancer Research
DNA repair
Cancer therapy
Reviews
Computational biology
Review
Biology
Metastasis
03 medical and health sciences
Transcription (biology)
medicine
Radiology, Nuclear Medicine and imaging
RC254-282
Cancer Biology
function
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cell migration
regulation
SET Protein
Cell cycle
medicine.disease
030104 developmental biology
Oncology
Apoptosis
cancer therapy
oncoprotein SET
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 7
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer medicineREFERENCES
- Accession number :
- edsair.doi.dedup.....903ca6890955ffa0fab1b0ad46c23b68