ACTION OF SEVERAL ANTI-HISTAMINICS ON THE ISOLATED RAT PHRENIC-DIAPHRAGM PREPARATION

Since Fourneau and Bovet (1) reported 2-isopropyl-5-methyl phenoxy-ethyl-diethylamine as a potent anti-histaminic, many publications on the central action of anti-histaminics have appeared during the last three decades. However, no report on the action of anti-histaminics to the neuromuscular junction has appeared, despite the fact that listlessness of the limbs occurs when a small dose of anti-histaminics is administered, as in the case of succinylcholine administration. In the present paper, the neuromuscular blocking property of several anti-histaminics was first screened, and then its mechanism of action was studied using rat phrenicdiaphragm preparation.