Back to Search
Start Over
Prediction of Mortality After Radical Prostatectomy by Charlson Comorbidity Index
Prediction of Mortality After Radical Prostatectomy by Charlson Comorbidity Index
- Source :
- Urology. 76:553-557
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- OBJECTIVES Prostate cancer treatment should depend on the characteristics of a patient's prostate cancer as well as overall health status. A possible adverse consequence of poor patient selection is a lack of benefit because of premature death from another cause. We evaluated the association between perioperative comorbidity and risk of death from causes other than prostate cancer in men who underwent radical prostatectomy (RP). METHODS We conducted a retrospective cohort study of 14,052 men who underwent RP from 1983 to 2006. The Charlson Comorbidity Index (CCI) score was calculated using the discharge records for the prostatectomy hospitalization. Mortality status and cause of death were obtained via chart review and searches of national databases. Cox proportional hazards regression was used to estimate the hazard ratio (HR) of death from causes other than prostate cancer after RP by CCI score (0, 1, 2+). RESULTS The median age at RP was 58.1 years. The median follow-up was 7.6 years (interquartile range 4.3-11.5). Of 849 deaths, 599 (70.6%) resulted from causes other than prostate cancer. On multivariable analysis, men with a CCI ≥2 had a statistically significantly higher risk of death from causes other than prostate cancer compared with those with lower CCI scores (HR 2.18, 95% CI 1.30-3.64, P = .0003). CONCLUSIONS Greater perioperative comorbidity was associated with a higher risk of death from causes other than prostate cancer in men who underwent RP. Physicians should consider using a standardized tool to assess perioperative comorbidities to enhance appropriate recommendation for surgical treatment.
- Subjects :
- Male
medicine.medical_specialty
Urology
medicine.medical_treatment
Comorbidity
Article
Cohort Studies
Prostate cancer
Interquartile range
Internal medicine
medicine
Humans
Retrospective Studies
Cause of death
Prostatectomy
business.industry
Hazard ratio
Prostatic Neoplasms
Retrospective cohort study
Perioperative
Middle Aged
Prognosis
medicine.disease
Surgery
business
Subjects
Details
- ISSN :
- 00904295
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Urology
- Accession number :
- edsair.doi.dedup.....905cb62be42442b33a7da15cebebf69a
- Full Text :
- https://doi.org/10.1016/j.urology.2010.02.069