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Plasma aldosterone and atrial mitochondrial functions of patients undergoing cardiac surgery
- Source :
- Future Cardiology. 16:275-280
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Aim: Mitochondrial dysfunction (MD) has been associated with poor outcomes after coronary artery bypass graft surgery. Methods: 58 consecutive patients from the ALDO-POAF Study (NCT02814903) were prospectively included. Plasma aldosterone was assessed at the time of the preoperative consultation and mitochondrial functional studies were performed using atrial appendage tissue collected during surgery. Results: Patients with the highest preoperative plasma aldosterone level had a lower mitochondrial respiratory chain functioning and a lower calcium retention capacity. Chronic kidney disease, patient’s age and preoperative high-aldosterone were independent predictors of MD in multivariate analysis. Conclusion: These exploratory data support the use of preventive strategies targeting aldosterone and/or mineralocorticoid receptor activation, in order to prevent perioperative MD and associated poor outcomes.
- Subjects :
- medicine.medical_specialty
Atrial Appendage
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
Postoperative Complications
0302 clinical medicine
Mineralocorticoid receptor
Internal medicine
Atrial Fibrillation
medicine
Humans
030212 general & internal medicine
Cardiac Surgical Procedures
Aldosterone
business.industry
Perioperative
medicine.disease
Mitochondria
Cardiac surgery
medicine.anatomical_structure
Mitochondrial respiratory chain
chemistry
Cardiology
Molecular Medicine
Cardiology and Cardiovascular Medicine
business
Kidney disease
Artery
Subjects
Details
- ISSN :
- 17448298 and 14796678
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Future Cardiology
- Accession number :
- edsair.doi.dedup.....9077dc0b7a60419b6f706e9e11511236