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Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study
- Source :
- BMJ Open, BMJ Open, Vol 10, Iss 7 (2020)
- Publication Year :
- 2020
-
Abstract
- ObjectivesThe purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.DesignCross-sectional study.Setting22 university hospitals and affiliated clinics in Japan.Participants1719 Japanese women aged 17–90 years who were not receiving lipid-lowering therapy.MeasuresWe evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were divided into four groups by HDL-C level: low HDL-C (ResultsUnivariate regression analysis revealed a significant relationship between FMD and HDL-C (r=0.12, pConclusionsEndothelial function increased in relation to HDL-C levels. However, there was no association of HDL-C levels with endothelial function after adjustment of traditional cardiovascular risk factors in women.Trial registration numberUMIN000012950; Results.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Brachial Artery
Cross-sectional study
Cardiovascular risk factors
lcsh:Medicine
Cardiovascular Medicine
chemistry.chemical_compound
Young Adult
High-density lipoprotein
Japan
Internal medicine
medicine
lipid disorders
Humans
Trial registration
Triglycerides
Lipoprotein cholesterol
Aged
Aged, 80 and over
Cholesterol
business.industry
lcsh:R
Cholesterol, HDL
nutritional and metabolic diseases
Regression analysis
General Medicine
vascular medicine
Middle Aged
University hospital
Vasodilation
Cross-Sectional Studies
chemistry
cardiology
lipids (amino acids, peptides, and proteins)
Female
Endothelium, Vascular
business
Subjects
Details
- ISSN :
- 20446055 and 00001295
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- BMJ open
- Accession number :
- edsair.doi.dedup.....908384243fd22f0f4c55a974e1ab3593