Prognostic factors of key outcomes for motor neuron disease in a multiracial Asian population

Objective To determine potential prognostic factors for survival, need for feeding and ventilation support in motor neuron diseases (MND) patients in a multi-racial Asian population. Methods One hundred and four MND patients from the Singapore General Hospital (SGH) between January 2004 and December 2017 were reviewed. All relevant clinical data, demographic information were collected. Kaplan-Meier and cox regression model were performed to identify potential prognostic factors for crucial outcomes (survival, need for feeding support and ventilation support). Results Mean age of onset was 59.54± 10.91 years, Mean age of onset in Malays was significantly younger than that of other ethnic groups (Malay: 54.18±12.95years; Non-Malay: 60.39±10.38years, p=0.035). Fifty six of the male and 33of the female were diagnosed with ALS (90.3% vs 78.6% p=0.048). Mean overall survival duration from symptom onset was significantly longer in female than male patients (female: 39.2± 29.04 months; male: 29.4± 24.06months, P=0.03). Bulbar onset was a significant risk predictor for both the need of feeding support (HR=3.87, p