Back to Search
Start Over
Tumor habitat analysis by magnetic resonance imaging distinguishes tumor progression from radiation necrosis in brain metastases after stereotactic radiosurgery
- Source :
- European radiology. 32(1)
- Publication Year :
- 2021
-
Abstract
- The identification of viable tumor after stereotactic radiosurgery (SRS) is important for future targeted therapy. This study aimed to determine whether tumor habitat on structural and physiologic MRI can distinguish viable tumor from radiation necrosis of brain metastases after SRS. Multiparametric contrast-enhanced T1- and T2-weighted imaging, apparent diffusion coefficient (ADC), and cerebral blood volume (CBV) were obtained from 52 patients with 69 metastases, showing enlarging enhancing masses after SRS. Voxel-wise clustering identified three structural MRI habitats (enhancing, solid low-enhancing, and nonviable) and three physiologic MRI habitats (hypervascular cellular, hypovascular cellular, and nonviable). Habitat-based predictors for viable tumor or radiation necrosis were identified by logistic regression. Performance was validated using the area under the curve (AUC) of the receiver operating characteristics curve in an independent dataset with 24 patients. None of the physiologic MRI habitats was indicative of viable tumor. Viable tumor was predicted by a high-volume fraction of solid low-enhancing habitat (low T2-weighted and low CE-T1-weighted values; odds ratio [OR] 1.74, p
- Subjects :
- medicine.medical_specialty
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Brain Neoplasms
medicine.medical_treatment
Area under the curve
Magnetic resonance imaging
General Medicine
Radiosurgery
Magnetic Resonance Imaging
Targeted therapy
Necrosis
Tumor progression
medicine
Effective diffusion coefficient
Humans
Radiology, Nuclear Medicine and imaging
Radiology
business
Radiation Injuries
Neuroradiology
Subjects
Details
- ISSN :
- 14321084
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....9097ad9605804a5cf278320aed82586f