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Inflammatory breast cancer outcomes by breast cancer subtype: a population-based study
- Source :
- Future Oncology. 15:507-516
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- Aim: To assess the outcomes of breast cancer subtype in inflammatory breast cancer (IBC). Methods: We retrospectively assessed IBC patients from the SEER program. Results: We identified 626 patients, including 230 (36.7%),100 (17.6%), 113 (18.1%), and 173 (27.6%) patients with HoR+/HER2-, HoR+/HER2+, HoR-/HER2+, and HoR-/HER2- subtype disease, respectively. Multivariate analysis demonstrated that, using HoR+/HER2- subtype as reference, patients with HoR+/HER2+ subtype had better breast cancer-specific survival (BCSS) and overall survival (OS), and patients with HoR-/HER2- subtype had worse BCSS and OS, while BCSS and OS were comparable for HoR-/HER2+ subtype. Similar trends were observed in patients who received surgery, radiotherapy, chemotherapy or trimodality therapy. Conclusion: Breast cancer subtype is clinically useful for predicting survival outcome in IBC. The HoR+/HER2- subtype shows poorer survival outcome than HoR+/HER2+ subtype.
- Subjects :
- Adult
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
Kaplan-Meier Estimate
Disease
Inflammatory breast cancer
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
medicine
Humans
In patient
skin and connective tissue diseases
neoplasms
Aged
Neoplasm Staging
Chemotherapy
business.industry
Breast cancer subtype
General Medicine
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Radiation therapy
Population based study
Treatment Outcome
030104 developmental biology
Population Surveillance
030220 oncology & carcinogenesis
Female
Inflammatory Breast Neoplasms
Neoplasm Grading
business
SEER Program
Subjects
Details
- ISSN :
- 17448301 and 14796694
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Future Oncology
- Accession number :
- edsair.doi.dedup.....90985931c1a4df672857fa1a2b5adf9d