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IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus
- Source :
- Journal of virology. 82(9)
- Publication Year :
- 2008
-
Abstract
- Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulatory protein of bovine foamy virus (BFV). The interaction involves NID2 (IFP35/Nmi homology domain) of IFP35 and the central domain of BTas. The overexpression of IFP35 disturbs the ability of BTas to activate viral-gene transcription and inhibits viral replication. The depletion of endogenous IFP35 by interfering RNA can promote the activation of BFV, suggesting an inhibitory function of IFP35 in viral-gene expression. In addition, IFP35 can interact with the homologous regulatory protein of prototype FV and arrest viral replication and repress viral transcription. Our study suggests that IFP35 may represent a novel pathway of interferon-mediated antiviral activity in host organisms that plays a role in the maintenance of FV latency.
- Subjects :
- Gene Expression Regulation, Viral
Immunology
Cellular Response to Infection
Microbiology
Virus
Cell Line
Transactivation
Interferon
Transcription (biology)
Virology
medicine
Animals
Humans
RNA, Small Interfering
Spumavirus
Lung
Cells, Cultured
Regulation of gene expression
biology
Intracellular Signaling Peptides and Proteins
RNA
biology.organism_classification
Virus Latency
Viral replication
Insect Science
Trans-Activators
Cattle
Interferons
medicine.drug
Subjects
Details
- ISSN :
- 10985514
- Volume :
- 82
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of virology
- Accession number :
- edsair.doi.dedup.....9098b38041440e80eaedc09e18302bfb