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Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats
- Source :
- Gastroenterology. 109:1583-1588
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- Background & Aims We recently showed that intracisternal injection of apolipoprotein A-IV (apo A-IV), a protein produced by the small intestine in response to fat, inhibits gastric acid secretion. The aim of this study was to investigate the mechanism of acid inhibition by central apo A-IV. Methods Gastric acid secretion was determined in pylorus-ligated conscious rats. The effect of intracisternal injection of apo A-IV on gastric acid secretion stimulated by pentagastrin, bethanechol, or intracisternal thyrotropin-releasing hormone (central vagal stimulant) was examined. The effects of vagotomy, indomethacin, and adrenergic blockers on the acid inhibition of apo A-IV were examined to investigate the role of the vagal system, prostaglandin pathways, and adrenergic system. Results Intracisternal apo A-IV significantly inhibited pentagastrin-, bethanechol-, and thyrotropin-releasing hormone-stimulated gastric acid secretion in a similar fashion. Inhibition of pentagastrin-stimulated acid secretion by apo A-IV still occurred even in vagotomized rats. Yohimbine but not indomethacin or propranolol eliminated apo A-IV-induced inhibition of acid. Conclusions Intracisternal apo A-IV inhibits gastric acid secretion through α2-adrenergic receptors. The vagal pathway and the prostaglandin system are not involved in apo A-IV-induced acid inhibition.
- Subjects :
- Male
medicine.medical_specialty
Apolipoprotein B
medicine.medical_treatment
Adrenergic beta-Antagonists
Indomethacin
Adrenergic
Prostaglandin
Bethanechol
Vagotomy
Gastric Acid
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
medicine
Animals
Secretion
Thyrotropin-Releasing Hormone
Apolipoproteins A
Hepatology
biology
digestive, oral, and skin physiology
Gastroenterology
Brain
Rats
Pentagastrin
Endocrinology
chemistry
Depression, Chemical
biology.protein
Gastric acid
lipids (amino acids, peptides, and proteins)
medicine.drug
Subjects
Details
- ISSN :
- 00165085
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....909b3fc00ed8745f89a0d397765820a1