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SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease
- Source :
- Redox Biology, Vol 13, Iss C, Pp 301-309 (2017), Redox Biology
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Coronary artery disease (CAD) is the primary critical cardiovascular event. Endothelial cell and monocyte dysfunction with subsequent extravagant inflammation are the main causes of vessel damage in CAD. Thus, strategies that repress cell death and manage unsuitable pro-inflammatory responses in CAD are potential therapeutic strategies for improving the clinical prognosis of patients with CAD. SIRT1 (Sirtuin 1) plays an important role in regulating cellular physiological processes. SIRT1 is also thought to protect the cardiovascular system by means of its antioxidant, anti-inflammation and anti-apoptosis activities. In the present study, we found that the SIRT1 expression levels were repressed and the acetylated p53 expression levels were enhanced in the monocytes of patients with CAD. LOX-1/oxidative stress was also up-regulated in the monocytes of patients with CAD, thereby increasing pro-apoptotic events and pro-inflammatory responses. We also demonstrated that monocytes from CAD patients caused endothelial adhesion molecule activation and the adherence of monocytes and endothelial cells. Our findings may explain why CAD patients remain at an increased risk of long-term recurrent ischemic events and provide new knowledge regarding the management of clinical CAD patients.<br />Highlights • SIRT1 expression is repressed in monocytes from CAD subjects. • LOX-1 and oxidative stress were increased in monocytes from CAD subjects. • SIRT1 inhibition causes mitochondrial dysfunction and apoptosis in monocytes from CAD subjects. • Monocytes from CAD patients had an increased adherence to endothelial cells through SIRT1 repression.
- Subjects :
- 0301 basic medicine
Adult
Male
Programmed cell death
Clinical Biochemistry
Inflammation
Apoptosis
Coronary Artery Disease
030204 cardiovascular system & hematology
medicine.disease_cause
Biochemistry
Monocytes
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
SIRT1
Sirtuin 1
medicine
Human Umbilical Vein Endothelial Cells
Humans
CAD
cardiovascular diseases
lcsh:QH301-705.5
lcsh:R5-920
biology
business.industry
Monocyte
Organic Chemistry
Middle Aged
medicine.disease
Scavenger Receptors, Class E
Endothelial stem cell
030104 developmental biology
medicine.anatomical_structure
LOX-1
lcsh:Biology (General)
Oxidative stress
Immunology
biology.protein
Female
medicine.symptom
Tumor Suppressor Protein p53
business
lcsh:Medicine (General)
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....909e63be46ce77ae135d93d78bbd0577