Understanding the impact of inflammatory processes on ovarian ageing and fertility

The age-related decrease in female fertility occurs because of ovarian ageing, which is when the number of healthy ovarian follicles stored in the ovary declines as women get older. The factors that control the rate of age-associated follicle depletion is unknown. However, preliminary data from mouse models suggest that inflammation may be a causative factor in the ovarian ageing process. The goal of this thesis is to determine if inflammation contributes to ovarian ageing, with a focus on follicle number. In the long term, the information gained from this study will help us to develop new strategies to improve reproductive health for women in advanced reproductive age.