Back to Search
Start Over
Dynamic Remodelling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex
- Source :
- PLoS Biology, PLoS Biology, Vol 4, Iss 2, p e29 (2006)
- Publication Year :
- 2005
- Publisher :
- Public Library of Science, 2005.
-
Abstract
- Despite decades of evidence for functional plasticity in the adult brain, the role of structural plasticity in its manifestation remains unclear. To examine the extent of neuronal remodeling that occurs in the brain on a day-to-day basis, we used a multiphoton-based microscopy system for chronic in vivo imaging and reconstruction of entire neurons in the superficial layers of the rodent cerebral cortex. Here we show the first unambiguous evidence (to our knowledge) of dendrite growth and remodeling in adult neurons. Over a period of months, neurons could be seen extending and retracting existing branches, and in rare cases adding new branch tips. Neurons exhibiting dynamic arbor rearrangements were GABA-positive non-pyramidal interneurons, while pyramidal cells remained stable. These results are consistent with the idea that dendritic structural remodeling is a substrate for adult plasticity and they suggest that circuit rearrangement in the adult cortex is restricted by cell type–specific rules.<br />Chronic in vivo imaging of fluorescent-labeled neurons in adult mice reveals extension and retraction of dendrites in GABAergic non-pyramidal interneurons of the cerebral cortex.
- Subjects :
- Aging
Time Factors
QH301-705.5
Period (gene)
Biology
Plasticity
General Biochemistry, Genetics and Molecular Biology
gamma-Aminobutyric acid
Mice
Cortex (anatomy)
Neuroplasticity
medicine
Animals
Biology (General)
gamma-Aminobutyric Acid
Visual Cortex
General Immunology and Microbiology
General Neuroscience
Anatomy
Dendrites
Mus (Mouse)
Rats
Visual cortex
medicine.anatomical_structure
nervous system
Gene Expression Regulation
Cerebral cortex
Synopsis
GABAergic
General Agricultural and Biological Sciences
Neuroscience
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15457885 and 15449173
- Volume :
- 4
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS Biology
- Accession number :
- edsair.doi.dedup.....90ab8da52c6f050a812c868e5ea3380a