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Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children
Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children
- Source :
- Epilepsybehavior : EB. 15(2)
- Publication Year :
- 2008
-
Abstract
- The intracarotid amobarbital procedure (IAP) is routinely conducted as part of the presurgical evaluation of pediatric patients with epilepsy. The aim of the present study was to investigate the possibility that anesthetization failures are the result of interactions of carbonic anhydrase-inhibiting (CAI) medications with sodium amobarbital. An archival review of 81 cases conducted between 1999 and 2008 was performed across two pediatric epilepsy centers. chi(2) analysis was used to assess whether CAI medications interfered with the outcome of these procedures. Of 81 patients, 85.2% had conclusive findings. All of the remaining 14.8% with anesthetization failures were taking CAI medications at the time of the procedure. However, 53.8% of patients taking CAI medications had conclusive results. This suggests that these medications may interact with sodium amobarbital, raising the possibility of anesthetization failures in children prescribed CAI medications.
- Subjects :
- Male
genetic structures
Adolescent
Amobarbital
Functional Laterality
Behavioral Neuroscience
Epilepsy
Memory
medicine
Humans
Epilepsy surgery
Anesthesia
Carbonic Anhydrase Inhibitors
Child
Retrospective Studies
Pediatric epilepsy
Sodium Amobarbital
business.industry
Age Factors
Retrospective cohort study
medicine.disease
Neurology
Multicenter study
Anticonvulsants
Female
sense organs
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 15255069
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Epilepsybehavior : EB
- Accession number :
- edsair.doi.dedup.....90c7e627c80609622ea1857cdf006f4d