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Electromotive administration of guanethidine for treatment of reflex sympathetic dystrophy: a pilot study in eight patients
- Source :
- Journal of pain and symptom management. 9(1)
- Publication Year :
- 1994
-
Abstract
- Persistent neuropathic pain is associated with, diagnostic and therapeutic challenges that may be very difficult to resolve. This report describes eight patients with incapacitating, posttraumatic neuropathic pain characteristic of reflex sympathetic dystrophy (RSD) who were treated by electromotive administration of guanethidine into affected areas of skin. Following 1–5 treatments, six patients experienced complete resolution of all superficial symptoms of hyperalgesia, pain, pallor, coolness, and sweating of the affected areas. One patient demonstrated partial relief of these symptoms, and one patient failed to respond. The results of this preliminary study suggest that electromotive administration of the sympatholytic agent, guanethidine, may be useful in the treatment of some types of neuropathic pain. These findings justify the implementation of further controlled studies.
- Subjects :
- Adult
Guanethidine
Male
medicine.medical_treatment
Injections, Subcutaneous
Pilot Projects
Pallor
Sympatholytic
medicine
Humans
General Nursing
Aged
Chemotherapy
business.industry
Dystrophy
Middle Aged
Electronics, Medical
Pain, Intractable
Reflex Sympathetic Dystrophy
Anesthesiology and Pain Medicine
Anesthesia
Neuropathic pain
Hyperalgesia
Reflex
Female
Neurology (clinical)
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 08853924
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of pain and symptom management
- Accession number :
- edsair.doi.dedup.....90cae54fe9aa56414a7b517f0109d5b1