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The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 3, p e0174511 (2017)
- Publication Year :
- 2016
-
Abstract
- The goal of our study was to investigate the contribution of ABCB1 expression to the risk of clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 assay. Applying Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP), the single-nucleotide polymorphisms (SNPs) was tested. Using bisulphite pyrosequencing assay, we investigated the association of the ABCB1 DNA methylation levels and CR. It was shown that female, hypertension, and lower albumin levels increased the risk of CR (P
- Subjects :
- Male
Physiology
Drug Resistance
lcsh:Medicine
Blood Pressure
Artificial Gene Amplification and Extension
030204 cardiovascular system & hematology
Antiplatelet Therapy
Biochemistry
Vascular Medicine
Polymerase Chain Reaction
Pathogenesis
0302 clinical medicine
Animal Cells
Genotype
Medicine and Health Sciences
Medicine
Coronary Heart Disease
lcsh:Science
Promoter Regions, Genetic
Sex Characteristics
Multidisciplinary
DNA methylation
biology
Pharmaceutics
Methylation
Hematology
Middle Aged
Plaque, Atherosclerotic
Chromatin
Clopidogrel
Body Fluids
Nucleic acids
Blood
030220 oncology & carcinogenesis
Hypertension
Female
Epigenetics
Anatomy
Cellular Types
DNA modification
Chromatin modification
Research Article
Chromosome biology
Platelets
medicine.medical_specialty
Cell biology
ATP Binding Cassette Transporter, Subfamily B
Ticlopidine
Serum albumin
Cardiology
Single-nucleotide polymorphism
Research and Analysis Methods
Polymorphism, Single Nucleotide
03 medical and health sciences
Drug Therapy
Internal medicine
Albumins
Genetics
SNP
Humans
Genetic Predisposition to Disease
Molecular Biology Techniques
Molecular Biology
Blood Coagulation
Serum Albumin
Aged
Blood Cells
Biology and life sciences
business.industry
lcsh:R
Albumin
Proteins
DNA
Vascular System Injuries
Platelet Activation
Endocrinology
Gene Expression Regulation
biology.protein
lcsh:Q
Gene expression
business
Platelet Aggregation Inhibitors
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....911195d547e496f5f7817b2482a329b2