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Protein-protein interactions: Methods, databases, and applications in virus-host study

Authors :
Sara Aiman
Chunhua Li
Zeeshan Shaukat
Qurat ul Ain Farooq
Source :
World Journal of Virology
Publication Year :
2021
Publisher :
Baishideng Publishing Group Inc., 2021.

Abstract

Almost all the cellular processes in a living system are controlled by proteins: They regulate gene expression, catalyze chemical reactions, transport small molecules across membranes, and transmit signal across membranes. Even, a viral infection is often initiated through virus-host protein interactions. Protein-protein interactions (PPIs) are the physical contacts between two or more proteins and they represent complex biological functions. Nowadays, PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins. Scientists have used PPIs to find the molecular basis of certain diseases and also some potential drug targets. In this review, we will discuss how PPI networks are essential to understand the molecular basis of virus-host relationships and several databases which are dedicated to virus-host interaction studies. Here, we present a short but comprehensive review on PPIs, including the experimental and computational methods of finding PPIs, the databases dedicated to virus-host PPIs, and the associated various applications in protein interaction networks of some lethal viruses with their hosts.

Details

ISSN :
22203249
Volume :
10
Database :
OpenAIRE
Journal :
World Journal of Virology
Accession number :
edsair.doi.dedup.....911725f3e16806c795a74b112d89c473
Full Text :
https://doi.org/10.5501/wjv.v10.i6.288