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Intractable vasculitis, resorptive osteolysis, and immunity to type I collagen in type VIII Ehlers-Danlos syndrome
- Source :
- Arthritis and rheumatism. 34(11)
- Publication Year :
- 1991
-
Abstract
- A unique patient with type VIII Ehlers-Danlos syndrome and cutaneous vasculitis, resorptive osteolysis, and cardiac valvular disease is described. Collagen analyses identified morphologic and physical abnormalities of type I collagen. The patient's T lymphocytes could be propagated in vitro with type I collagen and produced a 60-kd lymphokine that bound this protein. Cellular autoimmunity to type I collagen may be responsible for this patient's intractable clinical condition.
- Subjects :
- Systemic disease
Pathology
medicine.medical_specialty
Osteolysis
T-Lymphocytes
Immunology
Autoimmunity
medicine.disease_cause
Rheumatology
medicine
Immunology and Allergy
Humans
Pharmacology (medical)
business.industry
Synovial Membrane
Lymphokine
Infant, Newborn
medicine.disease
Connective tissue disease
Ehlers–Danlos syndrome
Vasculitis, Leukocytoclastic, Cutaneous
Ehlers-Danlos Syndrome
Female
Collagen
Vasculitis
business
Type I collagen
Subjects
Details
- ISSN :
- 00043591
- Volume :
- 34
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Arthritis and rheumatism
- Accession number :
- edsair.doi.dedup.....911db467123af63a857c38be951a35c6