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Paraneoplastic neurologic disorders in small cell lung carcinoma
- Source :
- Neurology. 85:235-239
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Objective: To determine the frequency and range of paraneoplastic neurologic disorders (PNDs) and neuronal antibodies in small cell lung carcinoma (SCLC). Methods: Two hundred sixty-four consecutive patients with biopsy-proven SCLC were recruited at the time of tumor diagnosis. All patients underwent full neurologic examination. Serum samples were taken prior to chemotherapy and analyzed for 15 neuronal antibodies. Thirty-eight healthy controls were analyzed in parallel. Results: PNDs were quite prevalent (n = 24, 9.4%), most frequently Lambert-Eaton myasthenic syndrome (3.8%), sensory neuronopathy (1.9%), and limbic encephalitis (1.5%). Eighty-seven percent of all patients with PNDs had antibodies to SOX2 (62.5%), HuD (41.7%), or P/Q VGCC (50%), irrespective of their syndrome. Other neuronal antibodies were found at lower frequencies (GABAb receptor [12.5%] and N-type VGCC [20.8%]) or very rarely (GAD65, amphiphysin, Ri, CRMP5, Ma2, Yo, VGKC complex, CASPR2, LGI1, and NMDA receptor [all Conclusions: The spectrum of PNDs is broader and the frequency is higher than previously appreciated, and selected antibody tests (SOX2, HuD, VGCC) can help determine the presence of an SCLC.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
GABAB receptor
Article
Cohort Studies
medicine
Humans
Prospective Studies
Prospective cohort study
Aged
Chemotherapy
biology
business.industry
Limbic encephalitis
Middle Aged
medicine.disease
Serum samples
Small Cell Lung Carcinoma
Cross-Sectional Studies
HEK293 Cells
biology.protein
NMDA receptor
Female
Neurology (clinical)
Antibody
business
Follow-Up Studies
Paraneoplastic Syndromes, Nervous System
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....91249e89b8da174fe7cf7690214561a2