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Left ventricular diastolic function compared with T2* cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major
- Source :
- Journal of Magnetic Resonance Imaging. 22:229-233
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Purpose To compare left ventricular (LV) diastolic function with myocardial iron levels in beta thalassemia major (TM) patients, using cardiovascular magnetic resonance (CMR). Materials and Methods We studied 67 regularly transfused patients with TM and 22 controls matched for age, gender, and body surface area. The early peak filling rate (EPFR) and atrial peak filling rate (APFR) were determined from high-temporal-resolution ventricular volume-time curves. Myocardial iron estimation was achieved using myocardial T2* measurements. Results Myocardial iron loading was found in 46 TM patients (69%), in whom the EPFR correlated poorly with T2* (r = −0.20, P = 0.19). The APFR (r = 0.49, P < 0.001) and EPFR/APFR ratio (r = −0.62, P < 0.001) correlated better with T2*. The sensitivity of the diastolic parameters for detecting myocardial iron loading ranged from 4% (EPFR and APFR) to 17% (EPFR/APFR ratio). Conclusion Myocardial iron overload results in diastolic myocardial dysfunction, but low sensitivity limits the use of a single estimation for early detection of iron overload, for which T2* has a superior categorical limit of normality. J. Magn. Reson. Imaging 2005;22:229–233. © 2005 Wiley-Liss, Inc.
- Subjects :
- Adult
Male
medicine.medical_specialty
Iron Overload
Thalassemia
Cardiomyopathy
Diastole
Doppler echocardiography
Risk Assessment
Severity of Illness Index
Ventricular Function, Left
Reference Values
Internal medicine
Confidence Intervals
medicine
Humans
Blood Transfusion
Radiology, Nuclear Medicine and imaging
Probability
Body surface area
medicine.diagnostic_test
business.industry
Myocardium
beta-Thalassemia
Transfusion Reaction
Beta thalassemia
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Echocardiography, Doppler
Case-Control Studies
Heart failure
Cardiology
Female
Cardiomyopathies
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15222586 and 10531807
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Magnetic Resonance Imaging
- Accession number :
- edsair.doi.dedup.....913d44ee45eef5f237e1571ffbcb7a92