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Antiviral activity of ovotransferrin derived peptides
- Publication Year :
- 2005
-
Abstract
- Ovotransferrin and lactoferrin are iron-binding proteins with antiviral and antibacterial activities related to natural immunity, showing marked sequence and structural homologies. The antiviral activity of two hen ovotransferrin fragments DQKDEYELL (hOtrf219–227) and KDLLFK (hOtrf269–301 and hOtrf633–638) towards Marek’s disease virus infection of chicken embryo fibroblasts is reported here. These fragments have sequence homology with two bovine lactoferrin fragments with antiviral activity towards herpes simplex virus, suggesting that these fragments could have a role for the exploitation of the antiviral activity of the intact proteins towards herpes viruses. NMR analysis showed that these peptides, chemically synthetized, did not possess any favourite conformation in solution, indicating that both the aminoacid sequence and the conformation they display in the intact protein are essential for the antiviral activity.
- Subjects :
- Biophysics
Sequence (biology)
Chick Embryo
Biology
medicine.disease_cause
Antiviral Agents
Biochemistry
Virus
medicine
Animals
Molecular Biology
Cells, Cultured
Conalbumin
Innate immune system
Lactoferrin
Embryo
Cell Biology
Ovotransferrin
Peptide Fragments
Mardivirus
Herpes simplex virus
biology.protein
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....915a1dbaf3dbc49b3be6d993229aa4ea