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Fe(III)-based metal-organic framework-derived core-shell nanostructure: Sensitive electrochemical platform for high trace determination of heavy metal ions
- Source :
- Biosensorsbioelectronics. 94
- Publication Year :
- 2016
-
Abstract
- A new core-shell nanostructured composite composed of Fe(III)-based metal-organic framework (Fe-MOF) and mesoporous Fe3O4@C nanocapsules (denoted as Fe-MOF@mFe3O4@mC) was synthesized and developed as a platform for determining trace heavy metal ions in aqueous solution. Herein, the mFe3O4@mC nanocapsules were prepared by calcining the hollow Fe3O4@C that was obtained using the SiO2 nanoparticles as the template, followed by composing the Fe-MOF. The Fe-MOF@mFe3O4@mC nanocomposite demonstrated excellent electrochemical activity, water stability and high specific surface area, consequently resulting in the strong biobinding with heavy-metal-ion-targeted aptamer strands. Furthermore, by combining the conformational transition interaction, which is caused by the formation of the G-quadruplex between a single-stranded aptamer and high adsorbed amounts of heavy metal ions, the developed aptasensor exhibited a good linear relationship with the logarithm of heavy metal ion (Pb2+ and As3+) concentration over the broad range from 0.01 to 10.0nM. The detection limits were estimated to be 2.27 and 6.73 pM toward detecting Pb2+ and As3+, respectively. The proposed aptasensor showed good regenerability, excellent selectivity, and acceptable reproducibility, suggesting promising applications in environment monitoring and biomedical fields.
- Subjects :
- Materials science
Metal ions in aqueous solution
Inorganic chemistry
Biomedical Engineering
Biophysics
Analytical chemistry
02 engineering and technology
Biosensing Techniques
010402 general chemistry
01 natural sciences
Ferric Compounds
Nanocapsules
Metal
Adsorption
Limit of Detection
Specific surface area
Metals, Heavy
Electrochemistry
Metal-Organic Frameworks
Ions
Nanocomposite
General Medicine
021001 nanoscience & nanotechnology
Silicon Dioxide
0104 chemical sciences
Nanostructures
G-Quadruplexes
visual_art
visual_art.visual_art_medium
Metal-organic framework
0210 nano-technology
Mesoporous material
Biotechnology
Environmental Monitoring
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....9163bf946c2354b77913ad1bda4c0f30