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Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients
- Source :
- Annals of the Rheumatic Diseases
- Publication Year :
- 2009
- Publisher :
- BMJ Group, 2009.
-
Abstract
- Introduction Psoriasis susceptibility locus 4 (PSORS4) is a susceptibility locus for psoriasis vulgaris (PsV), a common inflammatory, hyperproliferative skin disorder. Recently, a deletion of 2 late cornified envelope ( LCE ) genes within epidermal differentiation complex on chromosome 1 was shown to be enriched in 1426 patients with PsV, suggesting compromised barrier function in deletion carriers. This genetic association was subsequently confirmed in a German cohort. Methods In order to investigate whether this variant also predisposes to psoriatic arthritis (PsA), this deletion and 3 single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium with it were genotyped in a case-control cohort of 650 patients and 937 control individuals of German origin. Results LCE deletion frequency did not significantly differ between patients with PsA and controls (65.0% vs 65.5%). Similarly, no evidence for association to the three SNPs was observed. Discussion This is the first non-human leucocyte antigen (HLA) risk factor predisposing only to skin type of psoriasis, supporting the concept of partially overlapping but different aetiological factors underlying skin and joint manifestations.
- Subjects :
- Adult
Male
Linkage disequilibrium
Adolescent
Immunology
Arthritis
Single-nucleotide polymorphism
General Biochemistry, Genetics and Molecular Biology
Linkage Disequilibrium
Cornified envelope
Psoriatic arthritis
Young Adult
Rheumatology
Gene Frequency
Cornified Envelope Proline-Rich Proteins
Psoriasis
Germany
Immunology and Allergy
Medicine
Humans
Genetic Predisposition to Disease
Genetic association
Genetics
business.industry
Haplotype
Arthritis, Psoriatic
Clinical and Epidemiological Research
medicine.disease
Case-Control Studies
Female
business
Gene Deletion
Subjects
Details
- Language :
- English
- ISSN :
- 14682060 and 00034967
- Volume :
- 69
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....916a328cf5b02d292890957f4351a605