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Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial
- Source :
- Gastroenterology Research and Practice, Vol 2017 (2017), Gastroenterology Research and Practice
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- Background. We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). Methods. Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). Results. Failure in step 7 (n=23) was the most common followed by step 3 (n=15) and step 6 (n=13). We did not find any differences of clinicopathological factors between success and failure group in steps 1~6. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI 2 and 80.3% in those with BMI ≥ 23 kg/m2 (P=0.028). Conclusions. Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.
- Subjects :
- medicine.medical_specialty
Hepatology
medicine.diagnostic_test
Article Subject
Esophagogastroduodenoscopy
business.industry
Sentinel lymph node
Gastroenterology
Sentinel node
Surgery
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Biopsy
Clinical Study
medicine
030211 gastroenterology & hepatology
In patient
lcsh:Diseases of the digestive system. Gastroenterology
lcsh:RC799-869
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 16876121
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Gastroenterology Research and Practice
- Accession number :
- edsair.doi.dedup.....916f5ea33bf462bc8e7e4484366bb3c6