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Recurrence of Preeclampsia in Northern Tanzania: A Registry-Based Cohort Study
- Source :
- PLoS ONE, Vol 8, Iss 11, p e79116 (2013), e79116, PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Objective: Preeclampsia occurs in about 4 per cent of pregnancies worldwide, and may have particularly serious consequences for women in Africa. Studies in western countries have shown that women with preeclampsia in one pregnancy have a substantially increased risk of preeclampsia in subsequent pregnancies. We estimate the recurrence risks of preeclampsia in data from Northern Tanzania. Methods: A prospective cohort study was designed using 19,811 women who delivered singleton infants at a hospital in Northern Tanzania between 2000and2008. A total of 3,909 women were recorded with subsequent deliveries in the hospital with follow up through 2010. Adjusted recurrence risks of preeclampsia were computed using regression models. Results: The absolute recurrence risk of preeclampsia was25%, which was 9.2-fold (95% CI: 6.4 - 13.2) compared with the risk for women without prior preeclampsia. When there were signs that the preeclampsia in a previous pregnancy had been serious either because the baby was delivered preterm or had died in the perinatal period, the recurrence risk of preeclampsia was even higher. Women who had preeclampsia had increased risk of a series of adverse pregnancy outcomes in future pregnancies. These include perinatal death (RR= 4.3), a baby with low birth weight (RR= 3.5), or a preterm birth (RR= 2.5). These risks were only partly explained by recurrence of preeclampsia. Conclusions: Preeclampsia in one pregnancy is a strong predictor for preeclampsia and other adverse pregnancy outcomes in subsequent pregnancies in Tanzania. Women with previous preeclampsia may benefit from close followup during their pregnancies. publishedVersion
- Subjects :
- Adult
medicine.medical_specialty
Birth weight
lcsh:Medicine
Antenatal care
Risk Assessment
Tanzania
Preeclampsia
Young Adult
Pre-Eclampsia
Pregnancy
Recurrence
Risk Factors
medicine
Humans
VDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
Prospective Studies
Registries
Obstetric care
lcsh:Science
Prospective cohort study
reproductive and urinary physiology
VDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801
Multidisciplinary
business.industry
Obstetrics
lcsh:R
Infant, Newborn
Pregnancy Outcome
Infant, Low Birth Weight
Stillbirth
medicine.disease
female genital diseases and pregnancy complications
Gestational diabetes
Low birth weight
Premature birth
embryonic structures
Premature Birth
Female
lcsh:Q
medicine.symptom
business
Research Article
Follow-Up Studies
Cohort study
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....91771f01060f9bf5156c62e0e8334d35