Back to Search
Start Over
An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain
- Source :
- Biochemical and biophysical research communications. 160(1)
- Publication Year :
- 1989
-
Abstract
- The ADP-ribosylation of GTP-binding proteins (G-proteins) catalyzed by pertussis toxin was inhibited by endogenous inhibitor activity in the membrane extract of bovine brain. Most of the activity appeared in the fractions eluted from a DEAE-Sephacel column by 0.5 M NaCl. The activity was heat-stable and sensitive to pronase K. The results suggest the presence of an endogenous inhibitor of pertussis toxin in bovine brain.
- Subjects :
- Hot Temperature
G protein
Biophysics
Endogeny
Pronase
Biology
Pertussis toxin
Biochemistry
Catalysis
GTP-binding protein regulators
Drug Stability
GTP-Binding Proteins
Freezing
Animals
Virulence Factors, Bordetella
Molecular Biology
Brain Chemistry
Adenosine Diphosphate Ribose
Chromatography
Binding protein
Biological activity
Cell Biology
Thionucleotides
Molecular biology
Pertussis Toxin
Guanosine 5'-O-(3-Thiotriphosphate)
ADP-ribosylation
Cattle
Guanosine Triphosphate
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 160
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....918f68515fa6e6ce07c1c9b541be3917