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Activatable19F MRI Nanoparticle Probes for the Detection of Reducing Environments
- Source :
- Angewandte Chemie International Edition. 54:1007-1010
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- (19)F magnetic resonance imaging (MRI) probes that can detect biological phenomena such as cell dynamics, ion concentrations, and enzymatic activity have attracted significant attention. Although perfluorocarbon (PFC) encapsulated nanoparticles are of interest in molecular imaging owing to their high sensitivity, activatable PFC nanoparticles have not been developed. In this study, we showed for the first time that the paramagnetic relaxation enhancement (PRE) effect can efficiently decrease the (19)F NMR/MRI signals of PFCs in silica nanoparticles. On the basis of the PRE effect, we developed a reduction-responsive PFC-encapsulated nanoparticle probe, FLAME-SS-Gd(3+) (FSG). This is the first example of an activatable PFC-encapsulated nanoparticle that can be used for in vivo imaging. Calculations revealed that the ratio of fluorine atoms to Gd(3+) complexes per nanoparticle was more than approximately 5.0×10(2), resulting in the high signal augmentation.
- Subjects :
- Fluorocarbons
medicine.diagnostic_test
Chemistry
Relaxation (NMR)
Contrast Media
Resonance
Nanoparticle
Gadolinium
Magnetic resonance imaging
General Medicine
General Chemistry
Catalysis
Ion
Fluorine-19 Magnetic Resonance Imaging
Silica nanoparticles
Magnetics
Paramagnetism
Nuclear magnetic resonance
Coordination Complexes
medicine
Nanoparticles
Molecular imaging
Subjects
Details
- ISSN :
- 14337851
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....91921f71649b7bc1e9e5748e8f66a6cb
- Full Text :
- https://doi.org/10.1002/anie.201409365