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Decreasing cytokeratin 17 expression in head and neck cancer predicts nodal metastasis and poor prognosis: The first evidence
- Source :
- Clinical Otolaryngology. 43:1010-1018
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- OBJECTIVES Cytokeratins (CKs) are mainly expressed in epithelial carcinomas and are valuable for making diagnoses and identifying metastatic status. Changes in the expression of individual CKs in certain carcinoma may be relevant to establishing a prognosis. However, the prognostic significance of CKs in head and neck squamous cell carcinoma (HNSCC) remains elusive. Herein, we investigated the diverse and unique expression patterns of Cytokeratin 13 (CK13) and Cytokeratin 17 (CK17) and assessed the role of CK17 as a predictor for HNSCC metastasis and prognosis. METHODS CK13 and CK17 expressions were evaluated using immunohistochemical tissue microarray (TMA) analysis with 106 patients of HNSCC. To clarify the characterisation of CK17 expression with respect to its ability in predicting metastatic disease, an in vitro study of cells migration/invasion assays was conducted. Furthermore, the correlation of CK17 expression to clinicopathologic variables and prognosis was analyzed using a serial statistical method. RESULTS CK13 was predominately expressed in non-cancerous tissues and was lost in HNSCC. Decreasing expression of CK17 correlated with cancerous cell migration and invasion (P
- Subjects :
- 0301 basic medicine
Tissue microarray
business.industry
Head and neck cancer
medicine.disease
Head and neck squamous-cell carcinoma
Metastasis
03 medical and health sciences
Cytokeratin
030104 developmental biology
0302 clinical medicine
Otorhinolaryngology
030220 oncology & carcinogenesis
Cancer cell
Carcinoma
medicine
Cancer research
Immunohistochemistry
business
Subjects
Details
- ISSN :
- 17494486 and 17494478
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Clinical Otolaryngology
- Accession number :
- edsair.doi.dedup.....91a359488752d1817e8d9f8e891a47c6