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Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119
- Source :
- ChemBioChem, 20(24), 2987-2990. Wiley-VCH Verlag, Cromm, P M, Adihou, H, Kapoor, S, Vazquez-Chantada, M, Davey, P, Longmire, D, Hennes, E, Hofer, W, Küchler, P, Chiarparin, E, Waldmann, H & Grossmann, T N 2019, ' Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 ', ChemBioChem, vol. 20, no. 24, pp. 2987-2990 . https://doi.org/10.1002/cbic.201900615, Chembiochem
- Publication Year :
- 2019
-
Abstract
- The acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α‐helical peptides that target UNC119a. By using the hydrocarbon peptide‐stapling approach, cell‐permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis.<br />Targeting molecular chaperones: Cell‐permeable peptidomimetics of a myristoylated peptide were obtained by hydrocarbon peptide stapling. These agents target the human acyl‐binding protein UNC119a, which plays a crucial role in cytokinesis, inducing the accumulation of cytokinetic and binucleated cells. This suggests UNC119a as a potential target for the inhibition of cytokinesis.
- Subjects :
- Models, Molecular
Protein Conformation, alpha-Helical
Peptidomimetic
Binucleated cells
Peptide
010402 general chemistry
01 natural sciences
Biochemistry
Protein–protein interaction
Acyl binding
trafficking
alpha-helixes
Humans
Amino Acid Sequence
Molecular Targeted Therapy
Molecular Biology
Adaptor Proteins, Signal Transducing
chemistry.chemical_classification
GNAT1
macrocyclization
010405 organic chemistry
Communication
Organic Chemistry
Lipid Metabolism
Communications
3. Good health
0104 chemical sciences
Cell biology
protein–protein interaction
chemistry
peptidomimetics
Molecular Medicine
lipids (amino acids, peptides, and proteins)
Peptides
Cytokinesis
HeLa Cells
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 14394227
- Database :
- OpenAIRE
- Journal :
- ChemBioChem, 20(24), 2987-2990. Wiley-VCH Verlag, Cromm, P M, Adihou, H, Kapoor, S, Vazquez-Chantada, M, Davey, P, Longmire, D, Hennes, E, Hofer, W, Küchler, P, Chiarparin, E, Waldmann, H & Grossmann, T N 2019, ' Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 ', ChemBioChem, vol. 20, no. 24, pp. 2987-2990 . https://doi.org/10.1002/cbic.201900615, Chembiochem
- Accession number :
- edsair.doi.dedup.....91a44fabdad54efc230d88f99c2ae89c
- Full Text :
- https://doi.org/10.1002/cbic.201900615