Back to Search
Start Over
Use of the ankle-brachial index combined with the percentage of mean arterial pressure at the ankle to improve prediction of all-cause mortality in type 2 diabetes mellitus: an observational study
- Source :
- Cardiovascular Diabetology, Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
- Publisher :
- BioMed Central, 2020.
-
Abstract
- BackgroundPeripheral artery disease (PAD) in the lower extremities is a common complication of type 2 diabetes and has been shown to be associated with mortality. The ankle-brachial index (ABI) is a simple noninvasive method to screen PAD, but this method has limited sensitivity. We hypothesized that using the percentage of mean arterial pressure (%MAP) in combination with the ABI would improve the prediction of mortality.MethodsWe retrospectively collected data from patients with type 2 diabetes who had undergone ABI and %MAP measurements at our hospital. We separated the cohort into four groups according to their ABI and %MAP values, and we examined whether these indices were associated with mortality.ResultsA total of 5569 patients (mean age, 65 ± 11 years) were enrolled. During the follow-up period (median, 22.9 months), 266 (4.8%) of the enrolled patients died. The combination of ABI and %MAP was significantly more effective than ABI alone for predicting mortality (C index of 0.62, 95% confidence interval [CI] of 0.57 to 0.65 vs. C index of 0.57, 95% CI of 0.53 to 0.62; P = 0.038). In multivariate analysis (with a reference group defined by ABI > 0.90 and %MAP ≤ 45%), the highest risk of mortality was seen in patients with ABI ≤ 0.90 and %MAP > 45% (hazard ratio = 2.045 [95% CI 1.420, 2.945], P ConclusionsThe use of %MAP alongside ABI appears to significantly improve the prediction of all-cause mortality in patients with type 2 diabetes.
- Subjects :
- Male
medicine.medical_specialty
Mean arterial pressure
lcsh:Diseases of the circulatory (Cardiovascular) system
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Risk Assessment
Peripheral Arterial Disease
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
Risk of mortality
Medicine
Humans
Ankle Brachial Index
Arterial Pressure
cardiovascular diseases
Mortality
Original Investigation
Aged
Retrospective Studies
Aged, 80 and over
Peripheral artery disease
business.industry
Diabetes
Type 2 Diabetes Mellitus
Blood Pressure Determination
Middle Aged
medicine.disease
Lower extremity artery disease
Prognosis
Confidence interval
Percentage of the mean arterial pressure
body regions
Ankle-brachial index
Diabetes Mellitus, Type 2
lcsh:RC666-701
Cohort
Female
Cardiology and Cardiovascular Medicine
business
Complication
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....91a92b8abef6d50c280fed42b725697d