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Novel strategies to diagnose prosthetic or native bone and joint infections

Novel strategies to diagnose prosthetic or native bone and joint infections

Authors :
Tristan Ferry
Géraldine Durand
Corinne Jay
Olivier Rochas
Alex van Belkum
Christine C. Ginocchio
Sébastien Lustig
Frédéric Laurent
Marie-Francoise Gros
Source :
Expert review of anti-infective therapy. 20(3)
Publication Year :
2021

Abstract

Introduction Bone and Joint Infections (BJI) are medically important, costly and occur in both native and prosthetic joints. Arthroplasties are expected to increase significantly in absolute numbers over time as well as the incidence of Prosthetic Joint Infections (PJI). Diagnosis of BJI and PJI is generally sub-optimal. The available diagnostic tests have variable effectiveness, are often below standard in sensitivity and/or specificity and carry a significant contamination risk during the collection of clinical samples. Improvement of diagnostics is urgently needed. Areas covered : We here provide a narrative review on current and future diagnostic microbiology technologies. Pathogen identification, antibiotic resistance detection and assessment of the epidemiology of infections via bacterial typing is considered useful for improved patient management. We here confirm the continuing importance of culture methods and the successful introduction of molecular, mass spectrometry-mediated and next generation genome sequencing technologies. The diagnostic algorithms for BJI must be better defined, especially in the context of the diversity of both disease phenotypes and clinical specimens rendered available. Expert opinion : Whether interventions in BJI or PJI are surgical or chemo-therapeutic (antibiotics and bacteriophages included), prior sensitive and specific pathogen detection remains a therapy-designing necessity. Innovative tests for earlier and more sensitive and specific detection of bacterial pathogens in BJI are urgently needed.

Details

ISSN :
17448336
Volume :
20
Issue :
3
Database :
OpenAIRE
Journal :
Expert review of anti-infective therapy
Accession number :
edsair.doi.dedup.....91b969ea392b652565e00a6775a65bf0