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HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax

Authors :
Angela Polania
Maria Romanelli
Umberto Bertazzoni
Julie Lodewick
Françoise Bex
Paola Righi
Marco Turci
Source :
Virology. (1):6-11
Publisher :
Elsevier Inc.

Abstract

HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-κB, as has been previously demonstrated for Tax-1.

Details

Language :
English
ISSN :
00426822
Issue :
1
Database :
OpenAIRE
Journal :
Virology
Accession number :
edsair.doi.dedup.....91c349c469607f549a2a234787b00ecb
Full Text :
https://doi.org/10.1016/j.virol.2009.01.003