Back to Search
Start Over
Diffusion and perfusion MRI of normal, preeclamptic and growth-restricted mice models reveal clear fetoplacental differences
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Diffusion-weighted MRI on rodents could be valuable to evaluate pregnancy-related dysfunctions, particularly in knockout models whose biological nature is well understood. Echo Planar Imaging’s sensitivity to motions and to air/water/fat heterogeneities, complicates these studies in the challenging environs of mice abdomens. Recently developed MRI methodologies based on SPatiotemporal ENcoding (SPEN) can overcome these obstacles, and deliver diffusivity maps at ≈150 µm in-plane resolutions. The present study exploits these capabilities to compare the development in wildtype vs vascularly-altered mice. Attention focused on the various placental layers—deciduae, labyrinth, trophoblast, fetal vessels—that the diffusivity maps could resolve. Notable differences were then observed between the placental developments of wildtype vs diseased mice; these differences remained throughout the pregnancies, and were echoed by perfusion studies relying on gadolinium-based dynamic contrast-enhanced MRI. Longitudinal monitoring of diffusivity in the animals throughout the pregnancies also showed differences between the development of the fetal brains in the wildtype and vascularly-altered mice, even if these disparities became progressively smaller as the pregnancies progressed. These results are analyzed on the basis of the known physiology of normal and preeclamptic pregnancies, as well as in terms of the potential that they might open for the early detection of disorders in human pregnancies.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Spatiotemporal encoding
Placenta
Early detection
lcsh:Medicine
Biology
Article
030218 nuclear medicine & medical imaging
Mice
03 medical and health sciences
Fetus
0302 clinical medicine
Pre-Eclampsia
Animal disease models
Pregnancy
Developmental biology
medicine
Animals
lcsh:Science
Echo-planar imaging
Multidisciplinary
Extramural
lcsh:R
Trophoblast
Development of the nervous system
Intrauterine growth
Placentation
Trophoblasts
Mice, Inbred C57BL
Perfusion
Diffusion Magnetic Resonance Imaging
030104 developmental biology
medicine.anatomical_structure
Preclinical research
Female
lcsh:Q
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....91c36a95237cb86c70f5717a46c7a495