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Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells
- Source :
- Toxicon, Toxicon, Elsevier, 2007, 49 (3), pp.306-317. ⟨10.1016/j.toxicon.2006.09.029⟩
- Publication Year :
- 2006
-
Abstract
- International audience; We studied the interactive effects of either binary or tertiary mixtures of Fusarium mycotoxins, deoxynivalenol (DON), zearalenone (ZEA), and fumonisin B1 (FB1) on the human intestinal cell line, Caco-2, using the endpoints including malonedialdehyde (MDA) production, inhibition of protein and DNA syntheses, DNA methylation, DNA fragmentation, and cell viability as measured by the neutral red (NR) test. The mixtures of mycotoxins reduce cellular viability in increasing order: [FB1+ZEA]
- Subjects :
- DNA damage
Cell Survival
Apoptosis
DNA Fragmentation
Biology
CELLULAR MACROMOLECULES SYNTHESIS
Toxicology
Fumonisins
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Fusarium
Malondialdehyde
DEUTEROMYCOTINA
Humans
Drug Interactions
Viability assay
Gene Silencing
Fragmentation (cell biology)
SYNTHESE
Zearalenone
030304 developmental biology
0303 health sciences
Fumonisin B1
DNA synthesis
FUSARIUM TOXIN
food and beverages
04 agricultural and veterinary sciences
DNA Methylation
Mycotoxins
CELL VIABILITY
040401 food science
LIGNEE CACO-2
Drug Combinations
Oxidative Stress
Enterocytes
Biochemistry
chemistry
[SDV.TOX]Life Sciences [q-bio]/Toxicology
INTERACTIVE EFFECT
DNA fragmentation
HUMAN INTESTINAL CACO-2 CELL
Lipid Peroxidation
Caco-2 Cells
Trichothecenes
DNA
Subjects
Details
- ISSN :
- 00410101
- Volume :
- 49
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Accession number :
- edsair.doi.dedup.....91c9613e979512ab372d7f148c712854
- Full Text :
- https://doi.org/10.1016/j.toxicon.2006.09.029⟩