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Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper
- Source :
- British Journal of Cancer, British Journal of Cancer, 123(6), 874-884. Nature Publishing Group
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Immunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Immunosenescence
medicine.medical_treatment
Antineoplastic Agents
Review Article
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Lung cancer
Immune Checkpoint Inhibitors
030304 developmental biology
0303 health sciences
Chemotherapy
Clinical Trials as Topic
business.industry
Immunotherapy
Radioimmunotherapy
medicine.disease
Clinical trial
Radiation therapy
Geriatric oncology
030220 oncology & carcinogenesis
Position paper
Non small cell
business
Non-small-cell lung cancer
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 123
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....922341b1c282a8a16f3c82fed54a4e94