Back to Search
Start Over
Future regenerative therapies for corneal disease
- Source :
- Current Opinion in Ophthalmology. 34:267-272
- Publication Year :
- 2023
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2023.
-
Abstract
- To highlight the progress and future direction of stem-cell based regenerative therapies for the treatment of corneal disease.Corneal stem cell-based therapies, such as limbal stem cell transplantation, corneal stromal stem cell transplantation, endothelial stem cell transplantation, and stem cell-derived extracellular vesicles have demonstrated promising results in the laboratory. Although most are still in preclinical development or early phase clinical trials, these stem cell-based therapies hold potential to facilitate tissue regeneration, restore native function, and inhibit pathologic disease processes such as fibrosis, inflammation, and neovascularization.Stem cell-based therapy offers a promising therapeutic option that can circumvent several of the challenges and limitations of traditional surgical treatment. This concise review summarizes the progress in stem-cell based therapies for corneal diseases along with their history, underlying mechanisms, limitations, and future areas for development.
- Subjects :
- Ophthalmology
General Medicine
Subjects
Details
- ISSN :
- 15317021 and 10408738
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Ophthalmology
- Accession number :
- edsair.doi.dedup.....92595a4e571ffd4412e59669867f6f3c
- Full Text :
- https://doi.org/10.1097/icu.0000000000000938