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Quantitative MRI Biomarkers of Cognitive Morbidity in Temporal Lobe Epilepsy

Authors :
Michael Seidenberg
Abhik Bhattacharya
Bruce P. Hermann
Tayo O. Oyegbile
Source :
Epilepsia. 47:143-152
Publication Year :
2006
Publisher :
Wiley, 2006.

Abstract

Summary: Purpose: To determine the relation between neuropsychological morbidity, quantitative magnetic resonance imaging (MRI) measures of whole brain structure, and clinical seizure factors reflecting epilepsy cause, course, and treatment. Methods: Quantitative MRI measurements of total (whole brain) cerebrospinal fluid (CSF) and gray- and white-matter volumes and clinical seizure features were examined in relation to summary indices of cognitive morbidity in 96 patients with temporal lobe epilepsy. MRI volumes were adjusted for intracranial volume (ICV), and cognitive scores were adjusted for age, education, and gender, based on a sample of 82 healthy controls. Results: Whole-brain volumes (gray, white, and CSF) were abnormal in chronic temporal lobe epilepsy patients compared with controls and were related significantly to neuropsychological morbidity, especially total CSF. Statistical modeling demonstrated that markers of total atrophy (CSF) was the primary mediator of the relation between clinical seizure variables and neuropsychological morbidity. Conclusions: Quantitative measurements of overall brain abnormality (atrophy) in temporal lobe epilepsy are clinically meaningful markers that are associated with increased cognitive morbidity. These biomarkers appear to mediate the adverse effects of some clinical seizure variables on cognition.

Details

ISSN :
15281167 and 00139580
Volume :
47
Database :
OpenAIRE
Journal :
Epilepsia
Accession number :
edsair.doi.dedup.....925b0df16c42f472a516013e9eb91f13
Full Text :
https://doi.org/10.1111/j.1528-1167.2006.00380.x