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Quantitative MRI Biomarkers of Cognitive Morbidity in Temporal Lobe Epilepsy
- Source :
- Epilepsia. 47:143-152
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Summary: Purpose: To determine the relation between neuropsychological morbidity, quantitative magnetic resonance imaging (MRI) measures of whole brain structure, and clinical seizure factors reflecting epilepsy cause, course, and treatment. Methods: Quantitative MRI measurements of total (whole brain) cerebrospinal fluid (CSF) and gray- and white-matter volumes and clinical seizure features were examined in relation to summary indices of cognitive morbidity in 96 patients with temporal lobe epilepsy. MRI volumes were adjusted for intracranial volume (ICV), and cognitive scores were adjusted for age, education, and gender, based on a sample of 82 healthy controls. Results: Whole-brain volumes (gray, white, and CSF) were abnormal in chronic temporal lobe epilepsy patients compared with controls and were related significantly to neuropsychological morbidity, especially total CSF. Statistical modeling demonstrated that markers of total atrophy (CSF) was the primary mediator of the relation between clinical seizure variables and neuropsychological morbidity. Conclusions: Quantitative measurements of overall brain abnormality (atrophy) in temporal lobe epilepsy are clinically meaningful markers that are associated with increased cognitive morbidity. These biomarkers appear to mediate the adverse effects of some clinical seizure variables on cognition.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Neuropsychological Tests
Temporal lobe
Central nervous system disease
Epilepsy
Atrophy
Cerebrospinal fluid
Internal medicine
medicine
Humans
Cerebrospinal Fluid
Brain Mapping
Models, Statistical
Neuropsychology
Brain
Cognition
Organ Size
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Epilepsy, Temporal Lobe
Neurology
Chronic Disease
Cardiology
Female
Neurology (clinical)
Abnormality
Cognition Disorders
Psychology
Neuroscience
Biomarkers
Subjects
Details
- ISSN :
- 15281167 and 00139580
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....925b0df16c42f472a516013e9eb91f13
- Full Text :
- https://doi.org/10.1111/j.1528-1167.2006.00380.x