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Correction of mitochondrial dysfunction by succinic acid derivatives under experimental cerebral ischemia conditions
- Source :
- Current Issues in Pharmacy and Medical Sciences, Vol 34, Iss 1, Pp 42-48 (2021)
- Publication Year :
- 2021
- Publisher :
- Walter de Gruyter GmbH, 2021.
-
Abstract
- The aim of the study. To evaluate the effect of succinic acid derivatives on changes of mitochondrial function in rats under cerebral ischemia conditions. Materials and methods. In this work, the effect of succinic acid, ethylmethylhydroxypyridine succinate, and acetylaminosuccinic acid at doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg (per os) on the change of the neuronal mitochondria function was studied. Cerebral ischemia was reproduced by the Tamura method. The following parameters were evaluated: changes in aerobic/anaerobic metabolism, mitochondrial membrane potential, the opening rate of the mitochondrial pore of transitional permeability and the activity of apoptotic systems. Results. During the study, it was found that the use of the test-compounds at doses of 100 mg/kg and 200 mg/kg contributed to an increase in ATP-generating activity, as well as the maximum respiration level and respiratory capacity, while accompanied by a decrease in the intensity of anaerobic metabolism reactions. Also, upon administration of the test succinic acid derivatives, an increase in the mitochondrial membrane potential and latent opening time of the mitochondrial pore transitional permeability were observed. Moreover, the activity of caspase-3 and apoptosis-inducing factor on groups treated by test objects at doses of 100 mg/kg and 200 mg/kg was significantly lower than that in untreated animals. Conclusion. The studied succinic acid derivatives contribute to the restoration of mitochondrial function in cerebral ischemia conditions, while the most effective dose can be considered to be 100 mg/kg.
- Subjects :
- 0301 basic medicine
Pharmacology
business.industry
Ischemia
General Medicine
medicine.disease
Biochemistry
cerebral ischemia
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
chemistry
Succinic acid
mitochondrial dysfunction
succinates
Medicine
sense organs
skin and connective tissue diseases
business
Molecular Biology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 23006676 and 2084980X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Current Issues in Pharmacy and Medical Sciences
- Accession number :
- edsair.doi.dedup.....9265d70d201b47966bdaea1b2d032390