Back to Search
Start Over
Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
- Source :
- Biomolecules & Therapeutics
- Publication Year :
- 2019
- Publisher :
- The Korean Society of Applied Pharmacology, 2019.
-
Abstract
- Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.
- Subjects :
- 0301 basic medicine
Ciliopathy
Review
Biology
Biochemistry
Ciliopathies
Energy homeostasis
03 medical and health sciences
0302 clinical medicine
Drug Discovery
Autophagy
medicine
Cilia
Cancer
Pharmacology
Cilium
medicine.disease
Cell biology
030104 developmental biology
030220 oncology & carcinogenesis
Molecular Medicine
Signal transduction
Intracellular
Subjects
Details
- ISSN :
- 20054483 and 19769148
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Biomolecules & Therapeutics
- Accession number :
- edsair.doi.dedup.....92a0dd3f5c146d35725980f44dfc0e57