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Immunotherapy for hepatocellular carcinoma: A review of potential new drugs based on ongoing clinical studies as of 2019
- Source :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 51(8)
- Publication Year :
- 2018
-
Abstract
- In the latest years, antineoplastic immunotherapy revolutionised the therapeutic landscape in oncology. First shown to be effective in melanoma and non-small cell lung carcinoma, immune checkpoint inhibitors are now being tested for the treatment of hepatocellular carcinoma (HCC). Preliminary results have been particularly promising. As a consequence, an increasing number of clinical trials are underway. The role of the immune system in carcinogenesis (with particular reference to tumour escape immune mechanisms), as well as the current immunotherapy trials for HCC in its different clinical scenarios, are the subject of this review. In particular, we aim to provide fresh updates about these novel therapeutic agents which promise to shape the future therapeutic scenario of HCC.
- Subjects :
- Oncology
medicine.medical_specialty
Carcinoma, Hepatocellular
medicine.medical_treatment
Antineoplastic Agents
Immune checkpoint inhibitor
Pembrolizumab
Antibodies, Monoclonal, Humanized
Immune checkpoint inhibitors
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Humans
Nivolumab
Tremelimumab
Randomized Controlled Trials as Topic
Hepatology
business.industry
Melanoma
Liver Neoplasms
Gastroenterology
Immunotherapy
Drugs, Investigational
medicine.disease
digestive system diseases
Clinical trial
030220 oncology & carcinogenesis
Hepatocellular carcinoma
030211 gastroenterology & hepatology
business
medicine.drug
Subjects
Details
- ISSN :
- 18783562
- Volume :
- 51
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....92aa01984fa056ec8512a92f0e22432e