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DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

Authors :
Paul Greengard
Noboru Hiroi
D. J. Surmeier
Wen Jie Song
Anthony A. Grace
James P. O'Callaghan
Douglas G. Cole
Charles C. Ouimet
Allen A. Fienberg
F. J. White
S. P. Onn
Eric J. Nestler
R. Corbett
Gretchen L. Snyder
D. B. Miller
Steven E. Hyman
Colin N. Haile
Paul G. Mermelstein
Donald C. Cooper
Jean-Antoine Girault
Akinori Nishi
A. Cheramy
Source :
Science. 281:838-842
Publication Year :
1998
Publisher :
American Association for the Advancement of Science (AAAS), 1998.

Abstract

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Details

ISSN :
10959203 and 00368075
Volume :
281
Database :
OpenAIRE
Journal :
Science
Accession number :
edsair.doi.dedup.....92ad80846dba9a833a5136e6a4a47d98
Full Text :
https://doi.org/10.1126/science.281.5378.838