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DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
- Source :
- Science. 281:838-842
- Publication Year :
- 1998
- Publisher :
- American Association for the Advancement of Science (AAAS), 1998.
-
Abstract
- Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.
- Subjects :
- Male
Dopamine and cAMP-Regulated Phosphoprotein 32
medicine.medical_specialty
Dopamine
Dopamine Agents
Glutamic Acid
Nerve Tissue Proteins
Neurotransmission
Biology
Pharmacology
Receptors, N-Methyl-D-Aspartate
Synaptic Transmission
Mice
chemistry.chemical_compound
Cocaine
Internal medicine
Salicylamides
Phosphoprotein Phosphatases
medicine
Animals
Phosphorylation
Neurotransmitter
gamma-Aminobutyric Acid
Neurons
Raclopride
Multidisciplinary
Behavior, Animal
Receptors, Dopamine D1
Amphetamines
Dopaminergic
Genes, fos
Phosphoproteins
Cyclic AMP-Dependent Protein Kinases
Adenosine
Corpus Striatum
Mice, Inbred C57BL
PPP1R1B
Endocrinology
Gene Expression Regulation
chemistry
Gene Targeting
Forebrain
Calcium
Female
Sodium-Potassium-Exchanging ATPase
medicine.drug
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 281
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....92ad80846dba9a833a5136e6a4a47d98
- Full Text :
- https://doi.org/10.1126/science.281.5378.838