Back to Search
Start Over
A randomised, open label, controlled trial on the effect of interferon plus amantadine compared with interferon alone for treatment of chronic hepatitis C
- Source :
- Hepatology Research. 26:167-173
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Background: Combination of the antiviral drug amantadine with interferon (IFN) may be more effective than IFN monotherapy for treatment of chronic hepatitis C. Methods: We randomised 93 patients with chronic hepatitis C to IFNIFN 6 MU 3 times/week for 24 weeks, followed by IFN 3 MU 3 times/week for further 24 weeks given in combination with amantadine 100 mg t.i.d. (regimen A, n=48) or as monotherapy (regimen B, n=45). Control liver biopsies were obtained 6 months post treatment. Results: At the end of the trial a similar proportion of patients had normal serum ALT levels (35% for regimen A, and 44% for regimen B) as measured by intention to treat criteria. Sustained biochemical response at 6 months post treatment was 15 and 20%, and sustained virological response was 10 and 20% for regimen A and B, respectively. The effect on liver histology was also similar: the inflammatory components of the Knodell score decreased by 1.3±0.6 points for regimen A and by 1.6±0.6 for regimen B, and score for fibrosis remained unchanged with both regimens. Conclusions: Combination of IFN therapy with amantadine does not enhance the effect of IFN as shown by biochemical, virological and histological criteria.
- Subjects :
- medicine.medical_specialty
Intention-to-treat analysis
Hepatology
medicine.drug_class
business.industry
Hepatitis C virus
Amantadine
medicine.disease_cause
medicine.disease
Gastroenterology
law.invention
Regimen
Infectious Diseases
Randomized controlled trial
law
Interferon
Fibrosis
Internal medicine
Immunology
medicine
Antiviral drug
business
medicine.drug
Subjects
Details
- ISSN :
- 13866346
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Hepatology Research
- Accession number :
- edsair.doi.dedup.....92c02c822bab22d12ea7b6cec78bc812