Back to Search
Start Over
Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses
- Source :
- Behavioural Brain Research. 263:90-97
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Stressors during early life induce anxiety- and depressive-like responses in adult rodents. Siberian hamsters (Phodopus sungorus) exposed to short days post-weaning also increase adult anxiety- and depressive-like behaviors. To test the hypothesis that melatonin and exposure to stressors early in life interact to alter adult affective responses, we administered melatonin either during the perinatal (gestational day 7 to postnatal day 14) or postnatal (day 15–56) periods and also exposed a subset of dams to restraint during gestation (1 h–2×/day for 4 days). During the final week of injections, depressive-like behaviors were assessed using the sucrose anhedonia and forced swim tests. Hamsters exposed to prenatal restraint and treated with melatonin only during the postnatal period increased depressive-like responses in the forced swim test relative to all other groups. Offspring from restrained dams increased the number of fecal boli produced during the forced swim test, an anxiety-like response. In the present study, prenatal restraint reduced CA1 dendritic branching overall and perinatal melatonin protected hamsters from this restraint-induced reduction. These results suggest that the photoperiodic conditions coincident with birth and early life stressors are important in the development of adult affective responses.
- Subjects :
- Male
Restraint, Physical
endocrine system
medicine.medical_specialty
Anhedonia
Phodopus
Offspring
Anxiety
Article
Melatonin
Behavioral Neuroscience
Dietary Sucrose
Pregnancy
Cricetinae
Internal medicine
medicine
Animals
Hippocampus (mythology)
CA1 Region, Hippocampal
Swimming
Neurons
Depressive Disorder
biology
Dendrites
biology.organism_classification
Endocrinology
Prenatal Exposure Delayed Effects
Gestation
Female
medicine.symptom
Psychology
Stress, Psychological
Behavioural despair test
medicine.drug
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 263
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....92d0ef19c1e128e5a2fc0159ad0a7e91