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Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review

Authors :
Antonio Oliva
Simone Grassi
Vilma Pinchi
Francesca Cazzato
Mónica Coll
Mireia Alcalde
Marta Vallverdú-Prats
Alexandra Perez-Serra
Estefanía Martínez-Barrios
Sergi Cesar
Anna Iglesias
José Cruzalegui
Clara Hernández
Victoria Fiol
Elena Arbelo
Nuria Díez-Escuté
Vincenzo Arena
Josep Brugada
Georgia Sarquella-Brugada
Ramon Brugada
Oscar Campuzano
Source :
Journal of Clinical Medicine, 2022, vol. 11, núm. 15, p. 4406, Articles publicats (IdIBGi), Oliva, Antonio Grassi, Simone Pinchi, Vilma Cazzato, Francesca Coll Vidal, Mònica Alcalde Masegu, Mireia Vallverdú-Prats, Marta Perez-Serra, Alexandra Martínez-Barrios, Estefanía Cesar, Sergi Iglesias, Anna Cruzalegui, Jose Carlos Hernández Cera, Clara Fiol, Victoria Arbelo, Elena Díez-Escuté, Nuria Arena, Vincenzo Brugada, Josep Sarquella Brugada, Geòrgia Brugada, Ramon Campuzano Larrea, Oscar 2022 Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review Journal of Clinical Medicine 11 15 4406, DUGiDocs – Universitat de Girona, instname
Publication Year :
2022

Abstract

Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.

Details

ISSN :
20770383
Volume :
11
Issue :
15
Database :
OpenAIRE
Journal :
Journal of clinical medicine
Accession number :
edsair.doi.dedup.....92d765b23a2d26d3c0fc1c54111c24e4